
The following information is a summary about Megace. It is not intended to replace a doctor's instructions.
What is megestrol?
Megestrol is a man-made chemical similar to the female hormone progesterone.
Megestrol is used to treat loss of appetite and weight loss because of disease. Megestrol is also
used in the treatment of advanced breast cancer and endometrial cancer.
Megestrol may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about megestrol?
Notify your doctor if you develop any side effects while taking megestrol.
What should I discuss with my healthcare provider before taking megestrol?
Before taking megestrol, tell your doctor if you have
You may not be able to take megestrol, or you may require a lower dose or
special monitoring during treatment if you have either of the conditions listed above.
Do not take this medication if you are pregnant or are planning a
pregnancy. Megestrol is in the FDA pregnancy category X. This means that megestrol is known to
cause birth defects. Megestrol may cause abnormal development of the sexual organs.
Megestrol may pass into breast milk and harm a nursing infant. Do not take this medication
without first talking to your doctor if you are breast-feeding a baby.
How should I take megestrol?
Take megestrol exactly as directed by your doctor. If you do not understand these directions,
ask your pharmacist, nurse, or doctor to explain them to you.
Take each pill with a full glass of water.
Shake the suspension form of megestrol well before measuring a dose. To ensure that you
get a correct dose, measure the suspension with a dose-measuring spoon or cup, not a regular
tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Store megestrol at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the
dose you missed and take only your next regularly scheduled dose, as directed. Do not take a double
dose of this medication unless otherwise directed by your doctor.
What happens if I overdose?
A megestrol overdose is unlikely to threaten life. Call an emergency room or poison control
center for advice.
Symptoms of a megestrol overdose are not known.
What should I avoid while taking megestrol?
There are no restrictions on food, beverages, or activity during treatment with megestrol unless
your doctor directs otherwise.
Megestrol side effects
Stop taking megestrol and seek emergency medical attention or call your doctor
immediately if you experience any of the following serious side effects:
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an allergic reaction (difficulty breathing; closing of your throat;
swelling of your lips, tongue, or face; or hives);
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sudden severe headache;
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changes in vision; or
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numbness or swelling in an arm or leg.
Other, less serious side effects may be more likely to occur. Notify your
doctor if you experience
Side effects other than those listed here may also occur. Talk to your doctor
about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect megestrol?
Before taking megestrol, tell your doctor if you are taking insulin or an oral diabetes medicine
such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese),
tolazamide (Tolinase), or tolbutamide (Orinase). Megestrol may decrease the effects of these
medications, and your blood sugar level may increase. If you have diabetes, monitor your blood sugar
and talk to your doctor if you notice any unusual changes.
Drugs other than those listed here may also interact with megestrol. Talk to your doctor and
pharmacist before taking any prescription or over-the-counter medicines.
Where can I get more information?
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Your pharmacist has additional information about megestrol written for health professionals that
you may read.
What does my medication look like?
Megestrol is available with a prescription generically and under the brand name Megace. Other
brand and generic formulations may also be available. Ask your pharmacist any questions you have
about this medication, especially if it is new to you.
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Megace Oral Suspension 40 mg/mL--lemon-lime-flavored
suspension
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Megace 20 mg-light-blue, scored tablets
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Megace 40 mg-light-blue, scored tablets
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Remember, keep this and all other medicines out of the reach of children, never share your
medicines with others, and use this medication only for the indication prescribed.