The following information is a summary about Myocalm. It is not intended to replace a doctor's instructions.
Why is this medication prescribed?
Piracetam (brand name: Nootropil, Qropi, Myocalm, Dinagen, Synaptine) is a nootropic. It is a dietary supplement which is claimed to enhance cognition and memory, slow down brain aging, increase blood flow and oxygen to the brain, aid stroke recovery, and improve Alzheimer's, Down syndrome, dementia, and dyslexia, among others. Piracetam is prescribed by doctors for some conditions, mainly myoclonus,1 but is used off-label for a much wider range of applications. However, some treat it as a food supplement rather than a drug.
Effects
Several meta-reviews of literature on piracetam indicate that piracetam increases performance on a variety of cognitive tasks among dyslexic children, though this may reflect its enhancement of cross-hemispheric communication and of cognitive function in general, rather than a specific improvement in whatever causes dyslexia. Piracetam also seems to inhibit brain damage caused by a variety of factors including hypoxia and excessive alcohol consumption
Piracetam has been studied in an extensive number of clinical experiments, and has shown positive results in the treatment of post-stroke aphasia, epilepsy, cognitive decline following heart and brain surgery, dementia, and myoclonus.
Piracetam appears to increase communication between the two hemispheres of the brain, and increases activity of the corpus callosum.
Mechanisms of action
The mechanism of action of piracetam is not known, although it is hypothesized to act on ion channels or ion carriers, thus leading to non-specific increased neuron excitability, while explaining its lack of agonistic or inhibitory effect on synaptic action (quite unlike most neurotransmitters), and its low toxicity. It has been found to increase blood flow and oxygen consumption in parts of the brain but this may be a side-effect of increased brain activity rather than a primary effect or mechanism of action for the drug.
Piracetam improves the function of the neurotransmitter acetylcholine via muscarinic cholinergic (ACh) receptors which are implicated in memory processes. Furthermore, Piracetam may have an effect on NMDA glutamate receptors which are involved with learning and memory processes. Piracetam is thought to increase cell membrane permeability. Piracetam may exert its global effect on brain neurotransmission via modulation of ion channels (i.e., Na+, K+). It has been found to increase oxygen consumption in the brain, apparently in connection to ATP metabolism, and increases the activity of adenylate kinase in rat brain. Piracetam appears to increase the synthesis of cytochrome b5,[16] which is a part of the electron transport mechanism in mitochondria. It also increases the permeability of the mitochondria of some intermediaries of the Krebs cycle.
Approval and Usage
Piracetam is primarily used in Europe, Asia, South America and the US. Piracetam is legal to import into the United Kingdom and the United States for personal use with or without prescription. As of June 2006, piracetam is sold in the United States as a dietary supplement. As of July 2008, piracetam has no DIN number in Canada, and thus cannot be sold but can be imported for personal use. It has become popular as a cognitive enhancement drug among students, who often buy it in bulk as a powder and then consume it with orange or grapefruit juice to mask the strong, bitter taste. A two week regimen of piracetam was found to enhance verbal memory in healthy college students in a double-blind, placebo-controlled study. It is used by parents as a treatment for childhood autism, though no study has yet produced results which would support such a use.
Dosage
Piracetam is usually supplied in 800 mg tablets or capsules. Some bulk or nutritional suppliers supply it in a powder form. The recommended dosage varies based on the indication, usually ranging from 1.6-9.6 grams daily (2-12 pills daily). Some people report faster results when taking 1-2 pills every hour for 4-6 hours or taking 4-8 pills at once for the first few days to notice an effect.
For blood coagulation, clotting, and vasospastic disorders such as Raynaud's phenomenon or deep vein thrombosis, the most effective treatment range is a daily dose of 4.8 to 9.6 grams divided into three daily doses at 8 hours apart.
The LD-50 for oral consumption in humans has not been determined.
Contraindications
Piracetam is contra-indicated in patients with severe renal impairment (renal creatinine clearance of less than 20 ml per minute), hepatic (liver) impairment and to those under 16 years of age. It is also contraindicated in patients with cerebral haemorrhage and in those with hypersensitivity to piracetam, other pyrrolidone derivatives or any of the excipients.
What special precautions should I follow?
Due to the effect of piracetam on platelet aggregation, caution is recommended in patients with underlying disorders of hemostasis, major surgery or severe hemorrhage.
Abrupt discontinuation of treatment should be avoided as this may induce myoclonic or generalised seizures in some myoclonic patients.
As piracetam is almost exclusively excreted by the kidneys caution should be exercised in treating patients with known renal impairment. In renally impaired and elderly patients, an increase in terminal half-life is directly related to renal function as measured by creatinine clearance. Dosage adjustment is therefore required in those with mild to moderate renal impairment and elderly patients with diminished renal function.
What side effects can this medication cause?
Piracetam has been found to have very few side effects, and those it has are typically "few, mild, and transient. A large-scale, 12-week trial of high-dose piracetam found no adverse effects occurred in the group taking piracetam as compared to the placebo group. Many other studies have likewise found piracetam to be well-tolerated.
Symptoms of general excitability, including anxiety, insomnia, irritability, headache, agitation, nervousness, and tremor, are occasionally reported. Such symptoms seem more likely reported in connection with caffeine consumption (coffee), or with monosodium glutamate (a common additive in many processed foods). Effects can be reduced with magnesium supplements. Headache from use of piracetam may be alleviated by coadministration of an acetylcholine biosynthetic precursor, or a drug with cholinergic effects, such as choline bitartrate, choline citrate, lecithin, cyprodenate or centrophenoxine.
